| Ying Li,Xiao Juan Yang,Zhan Zhan Zhang,Xiao Ning Kang,Shang Long Liu. Accuracy of preoperative serum CA19-9 levels in predicting the resectability of patients with pancreatic adenocarcinoma. Oncol Transl Med, 2018, 4: 6-9. |
| Accuracy of preoperative serum CA19-9 levels in predicting the resectability of patients with pancreatic adenocarcinoma |
| Received:January 04, 2018 Revised:March 23, 2018 |
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| KeyWord:pancreatic adenocarcinoma; CA19-9; resectability |
| Author Name | Affiliation | E-mail | | Ying Li | Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | ly2016qyfy@163.com | | Xiao Juan Yang | Affiliated Hospital of Medical College,Qingdao University, Jiangsu Road
P R China | | | Zhan Zhan Zhang | Department of Nephropathy，Tengzhou Hospital of Traditional Chinese Medicine，Shandong Provence | | | Xiao Ning Kang | Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | | | Shang Long Liu | Department of General Surgery, Affiliated Hospital of Medical College，Qingdao University, 16 Jiangsu Road, Qingdao 266003, P. R. China | liushanglong-1@163.com |
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| Abstract: |
| Objective To assess the accuracy of preoperative serum CA19-9 levels in predicting the resectability of
pancreatic adenocarcinoma.
Methods Patients with biopsy-proven pancreatic adenocarcinoma who had preoperative serum CA19-9
level data were enrolled in the present retrospective analysis. Receiver operating characteristics (ROC)
curve analysis was used to determine the optimal cut-off value of CA19-9. The sensitivity, specificity,
positive predictive value, and negative predictive value were calculated at this cut-off point.
Results Seventy-six patients with pancreatic adenocarcinoma that was considered potentially resectable
according to radiological imaging were included. Of all 76 patients, 44 received complete resection of
the pancreatic adenocarcinoma. The preoperative serum CA19-9 level was significantly higher in the
unresectable tumor group than in the resectable tumor group (P = 0.0036). The area under the ROC
curve was 0.749 (95% confidence interval [CI]: 0.637–0.842). When the cut-off value of CA19-9 was set
to 359.1 U/mL, the sensitivity, specificity, positive and negative predictive values were 71.9% (95% CI:
53.3%–86.3%), 70.5% (95% CI: 54.8%–83.2%), 63.9% (95% CI: 46.0%–79.4%), and 77.5% (95% CI:
61.5%–89.2%), respectively.
Conclusion The preoperative serum CA19-9 level is useful for predicting the resectability of pancreatic
adenocarcinoma. |
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