Xin Cui,Caixin Zhang,Yunhui Li,Yongyun Qi,Xiaoyan Ding,Shumin Hei,Weiqing Huang. Function and clinical significance of SUMOylation in type I endometrial carcinoma. Oncol Transl Med, 2017, 3: 249-253.
Function and clinical significance of SUMOylation in type I endometrial carcinoma
Received:November 27, 2017  Revised:January 01, 2018
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KeyWord:SUMOylation; Ubc9; sentrin-specific peptidase 1 (SENP1); immunohistochemistry
Author NameAffiliationE-mail
Xin Cui Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China 846171214@qq.com 
Caixin Zhang Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China  
Yunhui Li Department of Obstetrics and Gynecology,affiliated medical college of Qingdao University  
Yongyun Qi Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China  
Xiaoyan Ding Department of Pathology,affiliated medical college of Qingdao University,Shandong QingdaoS China  
Shumin Hei Department of Pathology,the Third Affiliated Hospital of Qingdao University,Shandong QingdaoS China  
Weiqing Huang Department of Pathology,Qingdao municipal hospital,Shandong QingdaoS China  
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Abstract:
      Objective This study elucidated the function and role of SUMOylation in type I endometrial carcinoma. Methods Fifty type I endometrial carcinoma cases and para-cancer tissue samples were collected. The expression levels of ubiquitin-conjugating enzyme E2 I (Ube2i, Ubc9) and small ubiquitin-like modifier 1 (SUMO1)/sentrin-specific peptidase 1 (SENP1) proteins were examined using immunohistochemistry and the correlation with clinicopathological parameters was analyzed. Results Ubc9 expression in type I endometrial carcinoma tissues was significantly higher than that in the para-cancer tissues; in contrast, the expression of the SENP1 protein was markedly lower than that in the para-cancer tissues. Ubc9 and SENP1 expression levels were negatively correlated and were associated with tumor differentiation, but not age, depth of invasion, tumor stage, and lymph node metastasis. Conclusion SUMOylation modification plays a major role in the pathogenesis and development of type I endometrial carcinoma. Thus, it could be a potential target for the treatment of endometrial cancer.
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