| Li Ge,Hongwen Yao,Rong Zhang,Xiaoguang Li,Ling-Ying Wu. Papillary serous carcinoma of the uterine cervix: a clinicopathological analysis of 4 cases and a literature review. Oncol Transl Med, 2017, 3: 197-202. |
| Papillary serous carcinoma of the uterine cervix: a clinicopathological analysis of 4 cases and a literature review |
| Received:June 17, 2017 Revised:November 07, 2017 |
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| KeyWord:papillary serous carcinoma of uterine cervix (PSCC); clinicopathological features; prognosis analysis |
| Author Name | Affiliation | E-mail | | Li Ge | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | slwlaura@126.com | | Hongwen Yao | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Rong Zhang | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Xiaoguang Li | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Ling-Ying Wu | Department of Gynecologic Oncology, National Cancer Center / Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | wulingying@csco.org.cn |
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| Abstract: |
| Objective To investigate the clinicopathological characteristics and clinical treatment outcomes of
patients with papillary serous carcinoma of the uterine cervix (PSCC).
Methods In this study, 4 patients with histologically confirmed papillary serous carcinoma of the uterine
cervix were retrospectively investigated. Pap smears, human papillomavirus (HPV) screening, tumor
marker status, biopsy analysis, and relevant imaging examinations were conducted for the confirmation of
primary diagnosis and recurrence. Patients underwent surgery, chemotherapy, or radiotherapy, and survival
were the main endpoint.
Results The 4 patients were diagnosed with IB1, IB1, IIA, or IIIB disease. Two patients (2/4) presented
with recurrence within 18 months after primary therapy. Compared with chemotherapy alone (progressionfree
survival (PFS): 11 months), radiotherapy combined with adjuvant chemotherapy showed favorable
PFS rates (PFS: 20, 36, 13 months in 3 cases), although valid statistical analysis was not feasible because
of the small sample size. The 5-year survival rate was 0%, and the 3-year survival rate was 75%. Our data,
in agreement with the literature evidence, showed that the number of moderate-risk and high-risk factors in
patients diagnosed with PSCC at an early stage was higher than that in patients diagnosed with common
adenocarcinoma/squamous carcinoma of the uterine cervix.
Conclusion PSCC has a poor clinical prognosis, and compared with chemotherapy alone, radiotherapy
combined with adjuvant chemotherapy may lead to improved PFS. |
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