| Renyi Qin,Chunyang Ma,Xunjun Guo,Feng Zhu,Yuqi Ren,Hebin Wang,Min Wang. Retroperitoneal hyaline-vascular variant Castleman Disease in a patient with iron-deficiency anemia and sinus bradycardia: a case report. Oncol Transl Med, 2017, 3: 176-180. |
| Retroperitoneal hyaline-vascular variant Castleman Disease in a patient with iron-deficiency anemia and sinus bradycardia: a case report |
| Received:June 01, 2017 Revised:July 25, 2017 |
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| KeyWord:Castleman disease; sinus bradycardia; iron-deficiency anemia |
| Author Name | Affiliation | E-mail | | Renyi Qin | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | ryqin@tjh.tjmu.edu.cn | | Chunyang Ma | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Xunjun Guo | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Feng Zhu | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Yuqi Ren | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Hebin Wang | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | | | Min Wang | Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology | |
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| Abstract: |
| Castleman disease, also known as giant lymph node hyperplasia, involves lesions in the
lymph nodes usually located in the chest_ENREF_1, particularly in the mediastinum. Meanwhile, sinus
bradycardia is a sinus rhythm slower than 60 beats per min, and it can occur in both healthy and sick
individuals. However, the comorbidity of these two disorders has not been previously reported. In this
paper, we report a case of a 46-year-old woman who presented with persistent sinus bradycardia and irondeficiency anemia. Diagnostic work-up revealed hepatosplenomegaly and a giant mass near the splenic
hilum. The mass was removed surgically; after which, the patient’s bradycardia resolved immediately, while
her anemia was corrected after subsequent chemotherapy. Pathological examination revealed lymph nodes
with benign lesions, and the patient was diagnosed with hyaline-vascular variant of Castleman disease.
This is the first documented case of sinus bradycardia associated with Castleman disease. In this paper,
we describe the case characteristics, discuss the possible pathogenesis, and consider the appropriate
treatment of symptomatic sinus bradycardia accompanying Castleman disease. |
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