| Qinjiang Liu,Youxin Tian,Yaqiong Ni. Scabrous patrinia root inhibits circulating tumor cells in differentiated thyroid carcinoma – a clinical observation. Oncol Transl Med, 2017, 3: 181-184. |
| Scabrous patrinia root inhibits circulating tumor cells in differentiated thyroid carcinoma – a clinical observation |
| Received:April 19, 2017 Revised:October 25, 2017 |
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| KeyWord:scabrous patrinia root; Huikangling; differentiated thyroid carcinoma; flow cytometry; circulating tumor cell |
| Author Name | Affiliation | E-mail | | Qinjiang Liu | Department of Head and Neck Surgery, Gansu Provincial Cancer Hospital, Lanzhou 730050, China | Email: LIUQJ99@126.com | | Youxin Tian | Department of Head and Neck Surgery, Gansu Provincial Cancer Hospital, Lanzhou 730050, China | | | Yaqiong Ni | Department of Head and Neck Surgery, Gansu Provincial Cancer Hospital, Lanzhou 730050, China | |
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| Abstract: |
| Objective To observe the clinical inhibition of circulating tumor cells (CTCs) in differentiated thyroid
carcinoma (DTC) by the extract of scabrous patrinia root (Huikangling).
Methods Eighty-seven DTC patients tested positive for CTCs were randomly divided into two groups;
all patients were treated with oral levothyroxine sodium in accordance with the DTC endocrine inhibition
treatment criteria. Patients (n = 45) in the treatment group were provided the standard endocrine therapy
along with oral Huikangling (0.4 g/tablet, 0.4 g × 3 / time, 3 times / day, 12 weeks). Patients (n = 42) in
the control group were only provided the standard therapy. After 4 and 12 weeks, CTCs in the blood were
detected by flow cytometry.
Results After 4 weeks of oral Huikangling treatment, CTCs were detected in 18 (40%) and 29 (69%)
patients in the treatment and control groups, respectively; the difference was statistically significant (χ2 =
8.49, P < 0.05). After 12 weeks, CTCs were detected in 7 (15.6%) and 17 (44.7%) patients in the treatment
and control groups, respectively; the difference was statistically significant (χ2 = 5.68, P < 0.05). Follow-up
evaluation revealed two patients with lung metastasis and one patient with bone metastasis in the control
group; one patient showed lateral neck lymph node metastasis without local recurrence in the treatment
group.
Conclusion Huikangling treatment reduces the number of CTC-positive DTC cases; however, further
studies are needed to elucidate the underlying mechanisms. |
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