Fuli Zhang,Yadi Wang,Weidong Xu,Huayong Jiang,Junmao Gao,Qingzhi Liu,Na Lu,Diandian Chen,Bo Yao,Jun Hou,Heliang He,Jianping Chen. Comparison of the effects of two types of multileaf collimators on tumor control probability in radiotherapy for breast cancer after conservative surgery based on the EUD model. Oncol Transl Med, 2017, 3: 77-81.
Comparison of the effects of two types of multileaf collimators on tumor control probability in radiotherapy for breast cancer after conservative surgery based on the EUD model
Received:January 02, 2017  Revised:May 01, 2017
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KeyWord:tumor control probability (TCP); breast cancer; radiobiology; volumetric modulated arc therapy (VMAT)
Author NameAffiliationE-mail
Fuli Zhang Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng radiozfli@163.com 
Yadi Wang Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng wangyadi@hotmail.com 
Weidong Xu Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Huayong Jiang Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Junmao Gao Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Qingzhi Liu Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Na Lu Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Diandian Chen Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Bo Yao Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Jun Hou Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Heliang He Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
Jianping Chen Radiation Oncology Department,The PLA Army General Hospital of China,No. 5,Nanmencang,Dongcheng  
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Abstract:
      Objective To compute and compare the tumor control probability (TCP) of volumetric modulated arc therapy (VMAT) for breast cancer after conservative surgery based on two types of multileaf collimator (MLC) through a retrospective planning study. Methods For a group of 9 patients diagnosed with left breast cancer, VMAT plan based on Agility MLC and beam modulator (BM) MLC were designed. The prescription dose was 50 Gy covering at least 95% of the planning target volume, 2 Gy per fraction. TCPs were calculated according to dose-volume histogram (DVH) analysis. Results The TCP of the BM VMAT plan was slightly higher than that of the Agility VMAT plan (94.61% vs 94.23%) but was inferior with respect to delivery efficiency; the delivery time was reduced for Agility VMAT plan by 35% compared to BM VMAT plan. Conclusion For breast cancer radiation therapy after conservative surgery, BM VMAT plans provide slightly higher TCP while the delivery of Agility VMAT plans is significantly faster than the BM VMAT plans.
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