| Yuxuan Che,Xiaolei Ding,Huamin Qin,Lifen Wang,Xiuhua Sun. The expression of estrogen receptors in thyroid cancer and its significance. Oncol Transl Med, 2017, 3: 127-130. |
| 雌激素受体在甲状腺癌组织中的表达及其临床意义 |
| The expression of estrogen receptors in thyroid cancer and its significance |
| Received:December 28, 2016 Revised:June 05, 2017 |
| DOI：10.1007/s10330-016-0217-7 |
| 中文关键词: 甲状腺癌 雌激素受体 |
| 英文关键词: thyroid cancer; estrogen receptor (ER); pathological type |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Yuxuan Che | Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China | cheyuxu_an_ok@126.com | | Xiaolei Ding | Pathology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China | 3038668@vip.sina.com | | Huamin Qin | Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China | | | Lifen Wang* | Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China | 3038668@vip.sina.com | | Xiuhua Sun | Medical Oncology Department,The Second Affiliated Hospital,Dalian Medical University | |
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| 中文摘要: |
| 目的：检测雌激素受体（ER）在甲状腺癌组织中的表达情况，分析其与不同病理类型、临床特征的关系，探讨ER表达阳性患者的分布情况。方法：应用免疫组化方法检测56例甲状腺癌标本中ER的表达情况。采用χ2检验，分析ER在甲状腺癌组织及不同病理类型中的表达，采用Spearman进行等级相关分析ER表达与患者临床特征等的相关性。结果：1.甲状腺癌中ER表达阳性者36例，其中.乳头状癌48例，阳性表达者32例，滤泡状癌4例，阳性表达者2例，髓样癌4例，阳性表达者0例，在不同病理组织学类型中的表达有统计学差异。2.ER的表达与性别、年龄、TNM分期无关，无统计学差异。与淋巴结转移有关，有统计学差异。3.ER的表达与组织学类型、淋巴结转移呈负相关，Spearman相关系数分别为-0.313、-0.334。结论：ER在甲状腺癌组织中有表达，且ER的表达与性别、年龄、TNM分期无关，与组织学类型、淋巴结转移呈负相关。 |
| 英文摘要: |
| Objective?The study aimed to detect the expression of estrogen receptors (ERs) in thyroid cancer and investigate the correlation between their expression and clinical features and different pathological types.
Methods?The expression of ERs in 56 samples of thyroid cancer tissues was detected by an immunochemical approach. The expression of ERs in thyroid cancer tissues and different pathological types were analyzed using the χ2 test.
Results?The number of cases with positive expression of ER in thyroid cancer tissues was 36. The number of papillary thyroid cancers (PTCs) was 48, with positive expression of ERs in 32 cases. The number of follicular thyroid cancers was 4, with positive expression of ERs in 2 cases. The number of medullary thyroid cancers was 4, with negative expression of ERs in all cases. The difference between the expression and different pathological types showed statistical significance. The expression of ERs showed no correlation with sex, age, or TNM stage, with no statistical significance. However, the expression of ERs was correlated with metastasis of lymph nodes, which had statistical significance. The expression of ERs was negatively correlated with pathological types and metastasis of lymph nodes. The correlated coefficient index was –0.313 and –0.334, respectively.
Conclusion?The expression of ERs showed no correlation with sex, age, or TNM stage, but was negatively correlated with pathological types and metastasis of lymph nodes |
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