Yuxuan Che,Xiaolei Ding,Huamin Qin,Lifen Wang,Xiuhua Sun. The expression of estrogen receptors in thyroid cancer and its significance. Oncol Transl Med, 2017, 3: 127-130.
The expression of estrogen receptors in thyroid cancer and its significance
Received:December 28, 2016  Revised:June 05, 2017
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KeyWord:thyroid cancer; estrogen receptor (ER); pathological type
Author NameAffiliationE-mail
Yuxuan Che Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China cheyuxu_an_ok@126.com 
Xiaolei Ding Pathology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China 3038668@vip.sina.com 
Huamin Qin Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China  
Lifen Wang Medical Oncology Department, The Second Affiliated Hospital, Dalian Medical University, Dalian 116027, China 3038668@vip.sina.com 
Xiuhua Sun Medical Oncology Department,The Second Affiliated Hospital,Dalian Medical University  
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Abstract:
      Objective?The study aimed to detect the expression of estrogen receptors (ERs) in thyroid cancer and investigate the correlation between their expression and clinical features and different pathological types. Methods?The expression of ERs in 56 samples of thyroid cancer tissues was detected by an immunochemical approach. The expression of ERs in thyroid cancer tissues and different pathological types were analyzed using the χ2 test. Results?The number of cases with positive expression of ER in thyroid cancer tissues was 36. The number of papillary thyroid cancers (PTCs) was 48, with positive expression of ERs in 32 cases. The number of follicular thyroid cancers was 4, with positive expression of ERs in 2 cases. The number of medullary thyroid cancers was 4, with negative expression of ERs in all cases. The difference between the expression and different pathological types showed statistical significance. The expression of ERs showed no correlation with sex, age, or TNM stage, with no statistical significance. However, the expression of ERs was correlated with metastasis of lymph nodes, which had statistical significance. The expression of ERs was negatively correlated with pathological types and metastasis of lymph nodes. The correlated coefficient index was –0.313 and –0.334, respectively. Conclusion?The expression of ERs showed no correlation with sex, age, or TNM stage, but was negatively correlated with pathological types and metastasis of lymph nodes
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