| Gang Song,Shen Lin. Gastric molecular classification and practice in immunotherapy. Oncol Transl Med, 2017, 3: 10-14. |
| Gastric molecular classification and practice in immunotherapy |
| Received:August 26, 2016 Revised:January 23, 2017 |
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| KeyWord:molecular classification; gastric cancer; immunotherapy |
| Author Name | Affiliation | E-mail | | Gang Song | Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | happygang11@126.com | | Shen Lin | Department of GI Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | |
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| Abstract: |
| Gastric cancer (GC) is a highly heterogeneous malignancy with a high incidence worldwide; the prevalence
of GC is relatively higher in China than in other countries. Treatment of advanced GC has been slow to
develop due to lack of a proper classification system to guide clinical practice. With the development of
molecular biology techniques, the molecular classification of GC has been established and may have applications
in guiding precise and personalized therapy. To date, three or four molecular classifications for
GC have been recognized; these include Singapore, the Cancer Genome Atlas (TCGA) Research Network,
and Asian Cancer Research Group (ACRG) classifications. Here, we review the development of molecular
classifications and characteristics of different subtypes, and discuss the applications of molecular classifications
in clinical practice, with a focus on immunotherapy. |
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