| Panpan Zhang,Lin Shen. Circulating biomarkers for nonfunctional gastroenteropancreatic neuroendocrine neoplasm: Where do we stand?. Oncol Transl Med, 2017, 3: 15-19. |
| Circulating biomarkers for nonfunctional gastroenteropancreatic neuroendocrine neoplasm: Where do we stand? |
| Received:August 26, 2016 Revised:January 31, 2017 |
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| KeyWord:neuroendocrine neoplasm; biomarker; circulating tumor cells; NETest; microRNA |
| Author Name | Affiliation | E-mail | | Panpan Zhang | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Peking University, School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China | zppxmu@163.com | | Lin Shen | Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of GI Oncology, Peking University, School of Oncology, Beijing Cancer Hospital & Institute, Beijing 100142, China | linshenpku@163.com |
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| Abstract: |
| Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) encompass a heterogeneous group of
tumors associated with variable presentations, growth rates, and prognoses. The majority of GEP-NENs are
nonfunctional, and their diagnosis remains challenging given the often subtle and variable clinical manifestations
of these tumors. As a consequence, GEP-NENs are often recognized at an advanced stage; indeed,
most patients with nonfunctional GEP-NENs exhibit metastatic disease at diagnosis. Lack of treatment options
as well as limitations in currently available imaging modalities and biomarkers make it challenging to
manage NENs. Thus, novel biomarkers are needed to provide high sensitivity and specificity for minimum
disease detection and to predict treatment efficacy and prognosis. Although tissue-based biomarker data
can provide such information, circulating biomarkers such as NETests, circulating tumor cells, and microRNAs,
are superior owing to their easy accessibility and the ability for repeated real-time sampling. |
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