| Yi Li,Ruiqin Yue,Dongrui Qin,Yanqing Wang,Xinling Zhou,Xinyong Jing,Chuanzhong Wu. The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm. Oncol Transl Med, 2016, 2: 185-188. |
| The diagnostic value of tumor abnormal protein and high sensitivity C reactive protein in screening for endometrial cancer with endometrial thickness less than 8 mm |
| Received:May 27, 2016 Revised:August 11, 2016 |
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| KeyWord:tumor abnormal protein (TAP); high-sensitivity C-reactive protein (hs-CRP); endometrial thickness; endometrial carcinoma |
| Author Name | Affiliation | E-mail | | Yi Li | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Ruiqin Yue | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Dongrui Qin | Department of Pathology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Yanqing Wang | Department of Pathology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Xinling Zhou | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Xinyong Jing | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com | | Chuanzhong Wu | Department of Gynecology, The Second People’s Hospital of Liaocheng City, Shandong 252600, China | 15965259952@163.com |
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| Abstract: |
| Objective: This study aimed to combine tumor abnormal protein (TAP) and high-sensitivity C-reactive
protein (hs-CRP) level detection to diagnose endometrial cancer in patients with endometrial thickness less
than 8 mm, and to provide a reference for clinical screening and diagnosis.
Methods: Clinical data from 19 cases of endometrial cancer, diagnosed on the basis of pathological findings,
were collected from September 2014 to December 2015. The inclusion criteria were as follows: the
patients were first diagnosed with endometrial thickness less than 8 mm and were all in menopause. Perimenopausal
patients (n = 26) with uterine fibroids seen during the same period were selected as a control
group. Serum TAP and hs-CRP levels of the patients in the two groups were simultaneously determined
on admission.
Results: We found that both TAP and hs-CRP levels in the experimental group were higher than those
in the control group [(182.95 ± 72.14) μm2 vs. (133.19 ± 55.18) μm2, P = 0.019; (7.52 ± 19.03) mg/L vs.
(1.66 ± 2.31) mg/L, P = 0.136]. The sensitivity of TAP for the diagnosis of endometrial cancer was 73.68%,
the specificity was 69.23%, and the Youden index was 0.4291. The diagnostic sensitivity and specificity of
hs-CRP was 15.79% and 100%, respectively, and the Youden index was 0.1579. After plotting the receiver
operating characteristics curves, the optimal cut-off value for TAP in diagnosing endometrial cancer was
found to be 160.662 μm2 and that for hs-CRP was 1.07 mg/L.
Conclusion: For patients suspected of having endometrial cancer with endometrial thickness less than 8
mm, combined detection of TAP and hs-CRP levels can be used as a screening tool and can provide new
ideas regarding clinical diagnosis and treatment. |
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