Xiangmin Jia,Hongsheng Yu#. Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma. Oncol Transl Med, 2016, 2: 127-131.
Modulation of MMP-2 and TIMP-2 by low dose radiation in mice bearing S180 sarcoma
Received:March 30, 2016  Revised:June 08, 2016
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KeyWord:MMP-2; TIMP-2; low dose radiation; S180 sarcoma
Author NameAffiliationE-mail
Xiangmin Jia #Department of Oncology,The Affiliated Hospital of Qingdao University 386303816@qq.com 
Hongsheng Yu# #Department of Oncology,The Affiliated Hospital of Qingdao University qdhsyu@126.com 
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Abstract:
      Objective To investigate the inhibition of low dose radiation (LDR) on S180 sarcomas and its modulation of MMP-2 and TIMP-2 in mice. Methods S180 subcutaneously implanted tumor model mice were randomly divided into two groups: control (N) and low dose radiation (LDR) groups. N mice were sacrificed after 12 h, whereas LDR mice were sacrificed after 12 (LDR-12 h), 24 (LDR-24 h), 48 (LDR-48 h), and 72 (LDR-72 h) h. Thereafter, we measured the tumor volumes. Histopathology was performed, and P-V immunohistochemistry was applied to assess MMP-2 and TIMP-2 expression. Results Compared with the control group, the tumor growth was significantly inhibited in the LDR groups (P < 0.05). MMP-2 expression was considerably reduced in LDR-24h (P < 0.05) and LDR-48h (P < 0.05), whereas the change of TIMP-2 was not obvious in the LDR groups (P > 0.05) in contrast to that of the control group. Conclusion LDR can effectively suppress the growth of S180 implanted tumors by reducing MMP-2, which is associated with invasion and metastasis.
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