Huandi Zhou,Xiaohui Ge,Xiaoying Xue. microRNAs regulation and its role as biomarkers in diseases. Oncol Transl Med, 2016, 2: 39-46.
microRNAs regulation and its role as biomarkers in diseases
Received:August 04, 2015  Revised:January 25, 2016
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KeyWord:MicroRNA; cancer; disease; drug
Author NameAffiliationE-mail
Huandi Zhou Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China huandizhou@126.com 
Xiaohui Ge Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China xiaozihuirain@163.com 
Xiaoying Xue Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China xxy6412@163.com 
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Abstract:
      MicroRNAs (miRNAs), approximately 21 to 23 nucleotides (nt) in length, belong to a set of small non-coding RNA molecules that were not thought to be functional until the recent decades. miRNAs play important roles in many diseases such as various kinds of cancers and immune disorders. Many studies have focused on the relationship between miRNAs and diseases. miRNAs are significant mediators in human growth and development and in the genesis and development of diseases. Almost 30% of the activity of protein-coding genes is forecasted to be regulated by miRNAs in mammals, and some miRNAs are regarded as potential therapeutic targets for various diseases. In this review, we outline some functions of miRNAs, especially those related to diseases.
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