| Soumaya Ezzat,Hisham El Hossieny,Mohamed Abd Alla,Azza Nasr,Nagwan Anter,Ahmad Adel. A clinicoepidemiological study of esophageal cancer patients at the National Cancer Institute, Cairo University, Egypt. Oncol Transl Med, 2016, 2: 1-7. |
| A clinicoepidemiological study of esophageal cancer patients at the National Cancer Institute, Cairo University, Egypt |
| Received:June 09, 2015 Revised:June 24, 2015 |
| View Full Text View/Add Comment Download reader |
| KeyWord:esophageal cancer; epidemiology; retrospective trial |
| Author Name | Affiliation | E-mail | | Soumaya Ezzat | Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt | soumaya@yahoo.com | | Hisham El Hossieny | Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt | hishamelhossieny@yahoo.com | | Mohamed Abd Alla | Department of Clinical Oncology, Faculty of Medicine, Cairo University, Egypt | abdalla@yahoo.com | | Azza Nasr | Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt | nasrazza@hotmail.com | | Nagwan Anter | Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt | nagwan@yahoo.com | | Ahmad Adel | Misr University for Science and Technology, Egypt | Adel@hotmail.com |
|
| Hits: 6724 |
| Download times: 8912 |
| Abstract: |
| Objective: The purposes of this study were to (1) assess the clinicoepidemiological characteristics of esophageal cancer patients, (2) analyze the prognostic factors determining treatment failure and survival, and (3)
evaluate the results of various treatment modalities for locoregional and disseminated disease and their effect on disease-free survival and overall survival (OS).
Methods: Clinicoepidemiological retrospective data from 81 esophageal cancer patients treated at the National Cancer Institute of Cairo between 2007 and 2011 were evaluated.
Results: The study showed that patients with esophageal cancer commonly present with locally advanced disease (87.7% had T-stage 3 and 12.3% had T-stage 4). There was a significant correlation between surgery
and survival; patients who received radical surgery and postoperative radiation had a better median survival than patients who received radical radiotherapy (20 months vs. 16 months, respectively; P = 0.04). There was
also a significant statistical correlation between radical concomitant chemoradiotherapy (NCRT) and palliative treatment. Patients who received radical NCRT had a better median survival than patients who received palliative
radiotherapy (16 months vs. 10 months, respectively; P = 0.001). The median follow-up period for all patients was 7 months. The median OS of the whole group was 12 months. The OS after 1 and 2 years was
57.8% and 15%, respectively.
Conclusion: High-dose NCRT is an acceptable alternative for patients unfit for surgery or with inoperable disease. High-dose radiation is more effective than low-dose radiation in terms of local control, time to relapse,
and OS. Further study using a larger series of patients and introducing new treatment protocols is necessary for a final evaluation. |
| Close |
|
|
|