| Yingying Li,Sunan Wang,Peking University Shenzhen Hospital. Pathological characteristics and immunophenotype analysis of cervical intraepithelial neoplasia. Oncol Transl Med, 2016, 2: 285-289. |
| Pathological characteristics and immunophenotype analysis of cervical intraepithelial neoplasia |
| Received:May 15, 2015 Revised:May 15, 2015 |
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| KeyWord:cervical intraepithelial neoplasia; clinical pathology; protein; immunohistochemistry |
| Author Name | Affiliation | E-mail | | Yingying Li | Shenzhen Polytechnic College | wyk_150@163.com | | Sunan Wang | Shenzhen Polytechnic College | wyk_150@163.com | | Peking University Shenzhen Hospital | Peking University Shenzhen Hospital | |
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| Abstract: |
| Objective To explore the clinical pathological features and immunophenotypes of cervical intraepithelial
neoplasia (CIN).
Methods The protein expression of p16, p53, Bcl-2, and c-erbB-2 in 59 cases of CIN, 20 cases of cervical
squamous cell carcinoma, and 20 cases of normal cervical tissues were tested using immunohistochemistry
staining.
Results The expression rates of p16, p53, Bcl-2, and c-erbB-2 in CIN tissues were 76.3% (45/59), 28.85
(17/59), 61.0% (36/59), and 40.0% (23/59), respectively. The expression rates of p16, p53, Bcl-2, and
c-erbB-2 in cervical squamous cell carcinoma tissues were 60.0% (12/20), 60.0% (12/20), 75.0% (15/20),
and 65.0% (13/20), respectively. The expression rates of p16, p53, Bcl-2, and c-erbB-2 in normal cervical
tissues were 0.0% (0/20), 0.0% (0/20), 35.0% (7/20), 0.0% (0/20), respectively. In comparison to normal
tissues, the differential expressions of p16, p53, and Bcl-2 in squamous cell carcinoma and CIN were
statistically significant (P <0.001), whereas the difference between the squamous cell carcinoma and CIN
was not significant (P >0.05). In comparison to normal tissues, the differential expressions of c-erbB-2
and p53 in squamous cell carcinoma and CIN were statistically significant (P >0.05). The differential
expressions of Bcl-2, c-erbB-2, and p53 in CIN 3 were statistically significant in comparison to CIN 1 and
CIN 2 (P <0.05).
Conclusion Overexpression of Bcl-2 occurs early in the development of cervical cancer, whereas p16
and c-erbB-2 overexpression are markers for cell malignancy. The expression of p53 is correlated with the
development of cervical cancer. |
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