| Miao Li,Jun Li,Zhaozhen Qi,Qiu Tang,Xiangyang Wang,Hongda Lu. Role of inflammatory gene variants in Helicobacter pylori-related gastric cancer. Oncol Transl Med, 2015, 1: 104-108. |
| Role of inflammatory gene variants in Helicobacter pylori-related gastric cancer |
| Received:March 26, 2015 Revised:May 29, 2015 |
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| KeyWord:Helicobacter pylori (H. pylori); gastric cancer; gene variant; inflammatory |
| Author Name | Affiliation | E-mail | | Miao Li | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Jun Li | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Zhaozhen Qi | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Qiu Tang | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Xiangyang Wang | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | limiao0504@163.com | | Hongda Lu | Department of Oncology, Central Hospital of Wuhan, Wuhan 430000, China | phlonda@163.com |
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| Abstract: |
| Helicobacter pylori-related gastric cancer results from a chronic inflammatory process that arises from
atrophic gastritis, and develops into intestinal metaplasia, hyperplasia, and eventually gastric adenocarcinoma. Although approximately half of the world’s population is infected with Helicobacter pylori (H. pylori),
less than 3% of these infected individuals develop gastric cancer. H. pylori infection can cause both acute
and chronic inflammation, and may be present for decades within its host. Inflammatory gene variants are
particularly important factors that may influence a host’s susceptibility to H. pylori-related gastric cancer.
The inflammatory gene variants uncovered thus far include interleukin gene clusters, tumor necrosis factor-α, Toll-like receptors (TLRs), and inflammatory gene polymorphisms found in genome-wide association
studies (GWAS). The association between these gene variants and the risk of H. pylori-related gastric
cancer will aid in our understanding of the pathogenesis of gastric cancer in order to prevent and defeat
this malignancy. |
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