| Long Qin,Jing Ge. Expression of PinX1 and hTERT in basal cell carcinoma and their implications. Oncol Transl Med, 2015, 1: 140-143. |
| Expression of PinX1 and hTERT in basal cell carcinoma and their implications |
| Received:January 24, 2015 Revised:June 02, 2015 |
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| KeyWord:telomerase inhibitor 1 (PinX1); human telomerase reverse transcriptase (hTERT); basal cell carcinoma; real-time polymerase chain reaction; immunohistochemistry |
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| Abstract: |
| Objective This study aimed to investigate the expression and significance of PIN2/TERF1 interacting,
telomerase inhibitor 1 (PinX1) and human telomerase reverse transcriptase (hTERT) in basal cell carcinoma (BCC).
Methods Real-time polymerase chain reaction and immunohistochemistry were performed to quantify
the mRNA expressions and integrated optical density (IOD), respectively, of PinX1 and hTERT in BCC
specimens (n = 30), as well as in normal skin specimens (n = 15).
Results The mRNA expression level and IOD of PinX1 in the BCC samples were both significantly lower
than those in the control specimens (P < 0.05). Conversely, the mRNA expression level and IOD of hTERT
in BCC were both significantly higher than that in the control samples (P < 0.05). The correlation between
the expression levels of PinX1 and hTERT showed no statistical significance (P > 0.05).
Conclusion Downregulation of PinX1 and upregulation of hTERT expression may be associated with the
activation and maintenance of telomerases in the induction of BCC. |
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