| Ji Zhou,Daiyuan Ma,Yeqin Zhou,Xianfu Li,Bangxian Tan,Mi Liu,Tao Ren. Three-dimensional conformal radiotherapy plus concurrent DICE chemotherapy for early-stage nasal-type natural killer/T-cell lymphoma of Waldeyer’s ring: A single-institution study. Oncol Transl Med, 2015, 1: 181-185. |
| Three-dimensional conformal radiotherapy plus concurrent DICE chemotherapy for early-stage nasal-type natural killer/T-cell lymphoma of Waldeyer’s ring: A single-institution study |
| Received:January 07, 2015 Revised:July 25, 2015 |
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| KeyWord:nasal cavity; NK/T-cell lymphoma; prognosis; radiotherapy; chemotherapy |
| Author Name | Affiliation | E-mail | | Ji Zhou | the Affiliated Hospital, North Sichuan Medical College, | 41800451@qq.com | | Daiyuan Ma | the Affiliated Hospital, North Sichuan Medical College, | mdylx@163.com | | Yeqin Zhou | the Affiliated Hospital, North Sichuan Medical College, | nczyq1970@126.com | | Xianfu Li | the Affiliated Hospital, North Sichuan Medical College, | lixianfu13@163.com | | Bangxian Tan | the Affiliated Hospital, North Sichuan Medical College, | tbx_nsmc@126.com | | Mi Liu | the Affiliated Hospital, North Sichuan Medical College, | liumi212@yahoo.com.cn | | Tao Ren | the Affiliated Hospital, North Sichuan Medical College, | 584239854@qq.com |
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| Abstract: |
| Objective: Nasal-type natural killer/T-cell lymphoma of Waldeyer’s ring (WR-NK/TL) has different clinicopathological characteristics from those of other subtypes of NK/T lymphoma; thus, the optimal treatment remains unclear. To find a more effective treatment model for WR-NK/TL, we conducted a single-center study of concurrent radiochemotherapy.
Methods: Forty-five patients with newly diagnosed stage IE to IIE WR-NKTL were randomly divided into two groups. The 23 cases in the concurrent radiochemotherapy group were treated with three-dimensional conformal radiotherapy (48–52 Gy) and 2 courses of DICE (dexamethasone, ifosfamide, cisplatin, and etoposide) synchronous chemotherapy. The 22 cases in the radiotherapy group only received three-dimensional conformal radiotherapy (50–54 Gy). The primary end points were overall survival (OS), progressionfree survival (PFS), and toxicity.
Results: The 1-, 3-, and 4-year OS and PFS rates were 95.5%, 65.6%, and 45.9%, and 86.4%, 56.0%, and 46.7% in the radiotherapy group, and 100%, 88.5%, and 88.5%, and 100%, 82.0%, and 73.8% in the concurrent radiochemotherapy group, respectively. The OS (P = 0.0477) and PFS rates (P = 0.0488) were higher in the concurrent radiochemotherapy group than in the radiotherapy group. The overall response rate was 100% in both the radiotherapy group [complete response (CR), 18 cases] and concurrent radiochemotherapy group (CR, 22 cases). The concurrent radiochemotherapy group had more severe side effects, especially grade 3 4 events, such as leukopenia, anorexia, and stomatitis. However, side effects benefiting from excellent oral care were endurable.
Conclusion: Radiotherapy plus concurrent DICE chemotherapy may be an effective and safe comprehensive treatment for patients with WR-NKTL. |
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