Honghui Su. Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer. Oncol Transl Med, 2015, 1: 190-193.
Research progress of the role of HGF/c-Met in the proliferation, invasion, angiogenesis and metastasis of cancer
Received:December 28, 2014  Revised:July 30, 2015
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KeyWord:HGF/c-Met pathway; targeted therapy; drug resistance; clinical trial
Author NameAffiliationE-mail
Honghui Su Department of pharmacy Huabei Oilfield General Hospital Affiliated to Hebei Medical University cutesusu@sogou.com 
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Abstract:
      The HGF/c-Met pathway plays an important role in the proliferation, invasion, angiogenesis, and metastasis of tumors. With the successful development of small molecule c-Met kinase inhibitors, this signal pathway has become the focus of oncology research. In this review, we discuss the basic mechanism, targeted therapy, and early results of clinical trials of the HGF/c-Met pathway.
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