| Reham A. El Gendy,Ehab M. Attalla,Yasser M. Elkerm,Ali Alfarrash. Evaluating the influence of 6 MV and 15 MV photon beams on prostate intensity-modulated radiation therapy plans. Oncol Transl Med, 2016, 2: 26-33. |
| Evaluating the influence of 6 MV and 15 MV photon beams on prostate intensity-modulated radiation therapy plans |
| Received:December 15, 2014 Revised:February 19, 2016 |
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| KeyWord:intensity-modulated radiation therapy (IMRT); mixed-energy plans; 6 MV; 15 MV; prostate cancer; radiation treatment planning; dose-volumetric analysis |
| Author Name | Affiliation | E-mail | | Reham A. El Gendy | Ayadi Al Mostakbl Oncology Center, Alexandria, Egypt | attalla.ehab@gmail.com | | Ehab M. Attalla | National Cancer Institute, Cairo University, Cairo, Egypt | attalla.ehab@gmail.com | | Yasser M. Elkerm | Cancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, | attalla.ehab@gmail.com | | Ali Alfarrash | Faculty of Science, Mansoura University, Mansoura, Egypt | attalla.ehab@gmail.com |
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| Abstract: |
| Objective: We aimed to determine the effects of low- and high-energy intensity-modulated radiation therapy
(IMRT) photon beams on the target volume planning and on the critical organs in the case of prostate cancer.
Methods: Thirty plans were generated by using either 6 MV or 15 MV beams separately, and a combination
of both 6 and 15 MV beams. All plans were generated by using suitable planning objectives and dose constraints,
which were identical across the plans, except the beam energy. The plans were analyzed in terms of
their target coverage, conformity, and homogeneity, regardless of the beam energy.
Results: The mean percentage values of V70 Gy for the rectal wall for the plans with 6 MV, 15 MV, and mixedenergy
beams were 16.9%, 17.8%, and 16.4%, respectively, while the mean percentage values of V40 Gy were
53.6%, 52.3%, and 50.4%. The mean dose values to the femoral heads for the 6 MV, 15 MV, and mixed-energy
plans were 30.1 Gy, 25.5 Gy, and 25.4 Gy, respectively. The mean integral dose for the 6 MV plans was
10% larger than those for the 15 MV and mixed-energy plans.
Conclusion: These preliminary results suggest that mixed-energy IMRT plans may be advantageous with
respect to the dosimetric characteristics of low- and high-energy beams. Although the reduction of dose to the
organs at risk may not be clinically relevant, in this study, IMRT plans using mixed-energy beams exhibited
better OAR sparing and overall higher plan quality for deep-seated tumors. |
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