| Fuli Zhang,Xu Weidong,Jiang Huayong,Wang Yadi,Junmao Gao,Qingzhi Liu,Na Lu,Diandian Chen,Bo Yao,Jianping Chen,Heliang He. Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for treatment of cervical cancer. Oncol Transl Med, 2015, 1: 135-139. |
| Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for treatment of cervical cancer |
| Received:December 04, 2014 Revised:May 19, 2015 |
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| KeyWord:cervical neoplasm; helical tomotherapy; intensity-modulated radiotherapy (IMRT); dosimetry |
| Author Name | Affiliation | E-mail | | Fuli Zhang | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | radiozfli@163.com | | Xu Weidong | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | | | Jiang Huayong | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | | | Wang Yadi | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Junmao Gao | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Qingzhi Liu | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Na Lu | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Diandian Chen | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Bo Yao | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Jianping Chen | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com | | Heliang He | Radiation Oncology Department,The Military General Hospital of Beijing PLA,No. 5,Nanmencang,Dongcheng | wangyadi@hotmail.com |
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| Abstract: |
| Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy (BMS-IMRT) with intensity-modulated radiotherapy (IMRT) without entering the pelvic
bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy.
Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose
was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses
were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning
target volume homogeneity and conformity indices (HI and CI) as well as organ at risk dose and volume
parameters.
Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI.
V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%,
13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and
V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the
small bowel, bladder, and rectum.
Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy,
BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to
preventing acute hematologic toxicity |
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