| Xiaochen Hu,Junqiang Yang,Ruijie Yang,Ruina Yang,Xinshuai Wang,Shegan Gao. MicroRNAs in tumor stem cells. Oncol Transl Med, 2015, 1: 92-96. |
| MicroRNAs in tumor stem cells |
| Received:December 01, 2014 Revised:April 05, 2015 |
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| KeyWord:miRNAs; tumor stem cells; stemness |
| Author Name | Affiliation | E-mail | | Xiaochen Hu | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 54846673@qq.com | | Junqiang Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 369903863@qq.com | | Ruijie Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | 1032725019@qq.com | | Ruina Yang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | yrnwhw@foxmail.com | | Xinshuai Wang | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | xshuaiw@126.com | | Shegan Gao | Department of Oncology, Cancer Institute, the first Affiliated Hospital, Cancer Institute, Henan University of Science and Technology | gsg112258@126.com |
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| Abstract: |
| MicroRNAs (miRNAs) are a class of non-coding RNAs that are believed to have a significant role in tumorigenesis and cancer metastasis. Cancer stem cells play a major role in tumor recurrence, metastasis, and drug resistance. Research has shown that miRNAs can promote or inhibit the stemness of cancer stem cells and regulate the differentiation and self-renewal of cancer stem cells. In this article, the phenotype and regulatory mechanisms of miRNAs in cancer stem cells will be described, together with an explanation of their potential role in tumor diagnosis and treatment. |
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