Wenxi Yu,Yuanjue Sun,Yang Yao. Chinese experts’ consensus on diagnosis, prevention, and treatment of chemotherapy-induced hepatotoxicity. Oncol Transl Med, 2015, 1: 32-36.
Chinese experts’ consensus on diagnosis, prevention, and treatment of chemotherapy-induced hepatotoxicity
Received:October 20, 2014  Revised:October 20, 2014
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KeyWord:expert's consensus; hepatotoxicity
Author NameAffiliationE-mail
Wenxi Yu Department of Medical Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200033, China yaoyang_6@hotmail.com 
Yuanjue Sun Department of Medical Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200033, China yaoyang_6@hotmail.com 
Yang Yao Department of Medical Oncology, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200033, China yaoyang_6@hotmail.com 
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Abstract:
      Drug-induced liver injury (DILI, due to acetaminophen overdose and idiosyncratic drug reactions) often occurs 5 to 90 days after exposure to related drug. Among DILI cases, 90% are acute DILI. As one of the most common non-infectious liver diseases, DILI represents a growing challenge for clinicians. According to data from WHO [1], DILI is the 5th leading cause of liver disease mortality. In China, DILI accounts for 1%~5% of hospitalized patients with liver disease,10% of patients with acute hepatitis and 12.2% of patients with fulminant hepatitis[2]. A significant number of antitumor drugs have been proven, or at least suggested, to cause hepatotoxicity. Antitumor agents consist of cytotoxic drug, hormone, molecular targeted drug, biological response modifier and traditional drug. A retrospective review including 279 studies and 24112 patients pointed out that in China, antitumor drug ranked 5th among DILI-induced drugs[3]. Petronijevic[4] investigated data from 6370 patients with liver function failure from 38 countries and found out antitumor drug was the second leading cause for acute liver function failure, accounting for 11.9% of hospital admissions for hepatotoxicity. Mechanism for DILI is still unclear. It is a consensus that DILI is involved with multiple molecular mechanisms. Without specificity in symptoms and signs, DILI is often discovered by routine laboratory test. There are few ways to predict and prevent DILI.
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