| Renmin Hospital,Chen Wei,Zhao Yu,Zhou Zhongyin,Luo Hesheng,Xu Ximing. The roles of microRNAs and epithelial-mesenchymal transition in colorectal cancer metastasis. Oncol Transl Med, 2014, 13: 545-548. |
| The roles of microRNAs and epithelial-mesenchymal transition in colorectal cancer metastasis |
| Received:September 27, 2014 Revised:November 02, 2014 |
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| KeyWord:colorectal cancer (CRC), microRNA, epithelial-mesenchymal transition (EMT), metastasis |
| Author Name | Affiliation | Address | | Renmin Hospital | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | 武汉市解放路238号 | | Chen Wei | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Zhao Yu | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Zhou Zhongyin | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Luo Hesheng | Department of Gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China | | | Xu Ximing | Department of Oncology, Renmin Hospital, Wuhan University, Wuhan 430060, China | 湖北省武汉市解放路238号 |
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| Abstract: |
| Colorectal cancer (CRC) is the second most common cause of cancer death worldwide. Distant metastasis is the major cause of death in patients with CRC. During progression to metastasis in which malignant cells disseminate from the primary tumor to seeding other organs, a multistep process is involved. Cancer cells proliferate, invade microenvironment, enter into the blood circulation, then survive and colonize into distant organs. MicroRNAs (miRNAs) and epithelial-mesenchymal transition (EMT) are key regulators and mechanism in tumorigenesis and cancer metastasis. We review the roles of EMT and microRNAs, especially EMT related microRNAs in the metastatic pathway of CRC. MicroRNAs provide us a set of potential therapeutic applications and molecular target for CRC. |
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