| 倪雅琼,Jiangqin Liu,Youxin Tian. Clinical value of cancer cells joint detection in peripheral blood plasma of thyroid cancer patients. Oncol Transl Med, 2014, 13: 518-522. |
| Clinical value of cancer cells joint detection in peripheral blood plasma of thyroid cancer patients |
| Received:September 24, 2014 Revised:November 07, 2014 |
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| KeyWord:thyroid cancer; flow cytometry; circulating tumor cells; cytokeratin; polymorphic epithelial mucin |
| Author Name | Affiliation | Postcode | | 倪雅琼 | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | 730050 | | Jiangqin Liu | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | 730050 | | Youxin Tian | Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China | |
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| Abstract: |
| Objective: We aimed to detect cytokeratin 19 (CK19) and polymorphic epithelial mucin 1 (MUC1) expression in peripheral blood of thyroid cancer patients, and investigate the clinical value of it as a diagnostic marker for circulating blood micrometastases. Methods: The flow cytometry (FCM) was used to detect and analyze CK19 and MUC1-expressing cells in peripheral blood of 491 thyroid cancer patients. Results: CK19 and MUC1 expression showed no statistically significant difference with gender and age in thyroid cancer patients (P > 0.05), while had statistically significant difference with tumor size, lymph node stage and distant metastasis (P < 0.01). The expression of CK19 and MUC1 were positively correlated (r = 0.628, P = 0.00). Conclusion: CK19 is closely related to MUC1 expression, tumor size, extent of invasion and distant metastasis in peripheral blood of thyroid cancer patients. The circulating blood CK19 and MUC1 tests can help predict thyroid cancer micrometastases and prognosis. |
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