| Shuxian Qu,Zhendong Zheng,Zhaozhe Liu,Liang Liu,Miao Zhang,Yaling Han,Xiaodong Xie. Correlation between the expression of vascular endothelial growth factor c and C-erbB-2 in human breast cancer. Oncol Transl Med, 2014, 13: 464-467. |
| Correlation between the expression of vascular endothelial growth factor c and C-erbB-2 in human breast cancer |
| Received:August 15, 2014 Revised:September 26, 2014 |
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| KeyWord:breast cancer; vascular endothelial growth factor C; C-erbB-2 |
| Author Name | Affiliation | E-mail | | Shuxian Qu | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, China | qushuxian2010@163.com | | Zhendong Zheng | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Zhaozhe Liu | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Liang Liu | Oncology Department, The Thhird Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou, 550001, China | | | Miao Zhang | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Yaling Han | Cardiology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | | | Xiaodong Xie | Oncology Department, General Hospital of Shenyang Military Region, Shenyang, Liaoning 110840, China | doctor_xxd@163.com |
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| Abstract: |
| Objective: We aimed to study the transcription level of VEGF-C in human breast cancer tissue, and explore the correlations with the expression of C-erbB-2. Methods: The expression of VEGF-C mRNA in 51 cases of human breast cancer was assessed by hybridization in situ. The expressions of C-erbB-2 was assessed by immunohistochemistry. Results: The positive rate of VEGF-C mRNA was 54.9% in 51 cases of breast cancer. The transcription level had correlation with tumor size and status of lymph nodes (P < 0.05). The expression of VEGF-C mRNA had a positive correlation with the expression of C-erbB-2 (P < 0.05). Conclusion: The up-expression of VEGF-C has a significant correlation with the malignancy level and clinical stage of breast cancer. The combined detection of VEGF-C, C-erbB-2 may help to estimate the prognosis of patients with breast cancer and study on thetherapeutic implications. |
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