Shihong Ma,Jiangqin Liu,Xiaofeng Hou. Correlation between thyroid function and nodular goiter accompanied with gallstone. Oncol Transl Med, 2014, 13: 360-362.
Correlation between thyroid function and nodular goiter accompanied with gallstone
Received:July 30, 2014  Revised:July 30, 2014
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KeyWord:nodular goiter; gallstone; thyroid function
Author NameAffiliationE-mail
Shihong Ma Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China LIUQJ99@126.com 
Jiangqin Liu Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China LIUQJ99@126.com 
Xiaofeng Hou Department of Head-neck Surgical Oncology, Tumor Hospital of Gansu Province, Lanzhou 730050, China  
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Abstract:
      Objective: The purpose of the study is to explore the correlation between thyroid function and nodular goiter accompanied with gallstone. Methods: We collected 120 cases about nodular goiter accompanied with gallstone and 128 cases about nodular goiter and establish 50 healthy control groups. Detected t level of hyrotropic hormone (TSH), total triiodothyronine (TT3), total thyroxine in the peripheral venous blood of these cases in the three groups by using electrochemiluminescence immunoassay, measure level of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total bile acid (TBA) levels by using enzymic method, and observed the changes of thyroid function and blood lipid among the three groups. Results: The serum TT3 level in nodular goiter accompanied with gallstone group and the nodular goiter group was significantly lower than that in control group (P < 0.01), and TSH level in the nodular goiter accompanied with gallstone group is significantly higher than that in control group (P < 0.01). There were no statistical significance about difference of TT4 level among the three groups (P > 0.05). Accordingly, TC and LDL-C level in nodular goiter accompanied with gallstone group was significantly higher than that in nodular goiter and control group (P < 0.01), while TBA level in nodular goiter accompanied with gallstone group was significantly lower than that in simple nodular goiter group and control group (P < 0.01). There was no statistical significance about difference of TC and LDL-C level between simple nodular goiter group and control group (P > 0.05). The HDL-C level in nodular goiter accompanied with gallstone group and control group was higher than that in simple nodular goiter group (P < 0.01). Conclusion: The originating etiologic factor of nodular goiter accompanied with gallstone may be related to that the decreased TT3 induced sub-clinical hypothyroidism.
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