| Kui Li,Zhongyin Zhou,Ximing Xu,Hesheng Luo. Comparison of plastic and self-expandable metal stents in the palliative treatment of malignant biliary obstruction: a meta-analysis. Oncol Transl Med, 2014, 13: 375-378. |
| 比较塑料支架和金属支架治疗恶性胆道梗阻疗效的Meta分析 |
| Comparison of plastic and self-expandable metal stents in the palliative treatment of malignant biliary obstruction: a meta-analysis |
| Received:June 14, 2014 Revised:August 01, 2014 |
| DOI：10.1007/s10330-014-1349-5 |
| 中文关键词: 逆行胰胆管造影；支架置入；恶性胆道梗阻；Meta分析 |
| 英文关键词: ERCP; stent placement; malignant biliary obstruction; meta-analysis |
| 基金项目: |
| Author Name | Affiliation | E-mail | | Kui Li | Department of Gastroenterology, Renmin Hospital of Wuhan University | guimuyu@foxmail.com | | Zhongyin Zhou* | Department of Gastroenterology, Renmin Hospital of Wuhan University | zhouhu0425@163.com | | Ximing Xu | Cancer Center, Renmin Hospital of Wuhan University | | | Hesheng Luo | Department of Gastroenterology, Renmin Hospital of Wuhan University | |
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| 中文摘要: |
| 目的 ERCP治疗恶性胆道梗阻的方法主要是支架引流,包括塑料支架和金属支架，对比分析内置塑料支架与金属支架的疗效有一定的临床意义。方法 计算机检索中国知网（1915~2014.2）、万方数据库（1998~2014.2）和中国生物医学文献数据库（1978~2014.2），纳入ERCP内置塑料支架和金属支架对比研究的随机对照试验，并进行数据提取和文献评价。应用RevMan5.2进行统计分析。结果 本次分析共纳入8篇文献，共计633例行经内镜内置支架引流术。Meta分析结果显示，在首次支架置入中，塑料支架的阻塞率明显高于金属支架（66.8% vs 27.2%，P<0.00001）。 结论 塑料支架的阻塞率较金属支架高，预期生存期较短的患者可以选择塑料支架植入引流，而预计生存期较长的患者在经济能力能承受的情况下建议使用金属支架。 |
| 英文摘要: |
| Objective: Stent placement is one of the main methods in the palliative treatment of malignant biliary obstruction, including plastic and self-expandable metal stents. The comparison of stent patency between self-expandable metal and plastic stents in palliation of malignant biliary obstruction is meaningful. We carried out a meta-analysis to summarize current evidence for clinical efficacy of self-expandable metal and plastic stents in the treatment of malignant biliary obstruction. Methods: A comprehensive search of several databases including CNKI, WANFANG DATA, Sino MED. A fixed-effects or random-effects model was used to pool data of all study endpoint. Sensitivity analysis was also performed. Results: Eight randomized clinical trials were identified,including 633 patients. These results suggested that the self-expandable metal stents were associated with a significantly longer stent patency (OR=8.15; 95% CI: 2.80-23.76;I2=85%).No publication bias was observed. Conclusions: Self-expanding metal stents have a longer patency than plastic stents and offer adequate palliation in patients with malignant biliary obstruction. |
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