| Jing Zhang,Shiying Yu. The current G-CSF use in cancer patients with chemotherapy. Oncol Transl Med, 2014, 13: 288-290. |
| The current G-CSF use in cancer patients with chemotherapy |
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| KeyWord:granulocyte colony-stimulating factor (G-CSF); ASCO white blood cell growth factors guideline; NCCN myeloid growth factors guideline; febrile neutropenia; standardized use |
| Author Name | Affiliation | | Jing Zhang | Tongji Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China | | Shiying Yu | Tongji Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430031, China |
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| Abstract: |
| Objective: The purpose of the study was to survey current G-CSF use in cancer patients, investigate whether the use of granulocyte colony-stimulating factor (G-CSF) is standardized. Methods: From July 2012 to October 2012, patients in a third-grade class-A hospital were investigated by self-designed questionnaires, according to ASCO’s recommendations for white blood cell growth factors in 2006 and NCCN myeloid growth factors guideline in 2012. Results: Two hundred and twenty-two patients treated with 724 courses of chemotherapy were included. In prophylactic use, 259 (35.8%) cases used G-CSF that the guideline doesn’t recommend, which belonged to excessive use, the dose were 274 700 µg, accounting for 59.7% of the totle prophylactic use; 105 (14.5%) didn’t use while the guideline recommend, belonging to lack of use. 89.0% of the prophylactic use were 24–72 h after chemotherapy, only a few (5.4%) on the day of chemotherapy. In therapeutic use, only 3.1% were standardized, with the dose of 23 000 µg, accounting for 7.4% of the total. So 92.6% were excessive. 14.2% of the therapeutic use were 24–72 h after chemotherapy, 21.2% on the day of chemotherapy. Conclusion: More than 50% use of G-CSF weren’t standardized, especially the excessive use. |
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