| Chunni Xu,Hong Chen,Yan Zhou. Expression differences of serum prealbumin in benign and malignant colorectal tumors. Oncol Transl Med, 2014, 13: 280-282. |
| Expression differences of serum prealbumin in benign and malignant colorectal tumors |
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| KeyWord:colorectal cancer; colorectal adenoma; prealbumin |
| Author Name | Affiliation | | Chunni Xu | Department of Oncology, Yixing Hospital Affiliated to Jiangsu University, Yixing 214200, China | | Hong Chen | Department of Oncology, Yixing Hospital Affiliated to Jiangsu University, Yixing 214201, China | | Yan Zhou | Department of Oncology, Yixing Hospital Affiliated to Jiangsu University, Yixing 214202, China |
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| Abstract: |
| Objective: The aim of the study was to investigate the expression differences of serum prealbumin in patients with benign and malignant colorectal tumors and its clinical significance. Methods: The concentrations of total protein, albumin, prealbumin, hemoglobin of 113 colorectal cancer patients (cancer group) and 87 colorectal adenomas (adenoma group) were tested in Yixing Hospital Affiliated to Jiangsu University (China) during August 2013 to December 2013. Then the differences between the two groups were compared. Results: In colorectal cancer patients, the concentrations of serum prealbumin in 39/113 cases, total protein in 16/113 cases, albumin in 38/113, hemoglobin in 32/113 were lower than normal ranges. While, in colorectal adenoma patients, the concentrations of serum prealbumin in 4/87 cases, total protein in 2/87, albumin in 1/87, hemoglobin in 2/87 were below the detection limit. Comparative analysis showed that, average expression levels of serum prealbumin, albumin, total protein, hemoglobin in colorectal cancer patients were lower than those of colorectal adenoma patients, the difference was statistically significant (P < 0.05), and colorectal cancer patients were more likely to have lower levels of above indicators (P < 0.05). Conclusion: Compared to colorectal adenoma patients, patients with colorectal cancer have lower average expression levels, and were easier to have lower expression levels of serum albumin, albumin, total protein and hemoglobin, which suggest that colorectal cancer patients are more likely to have metabolic change, and clinic notable. |
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