| Yaqiong Ni,Qinjiang Liu,Shihong Ma,Ruihui Chen. Inhibition effects of parathyroid hormone on human medullary thyroid carcinoma cells. Oncol Transl Med, 2014, 13: 224-228. |
| Inhibition effects of parathyroid hormone on human medullary thyroid carcinoma cells |
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| KeyWord:parathyroid hormone (PTH); medullary thyroid carcinoma (MTC) cell line; parathyroid hormone receptor monoclonal antibody |
| Author Name | Affiliation | | Yaqiong Ni | Department of Head and Neck Surgery, The Cancer Hospital of Gansu Province, Lanzhou 730050, China | | Qinjiang Liu | Department of Head and Neck Surgery, The Cancer Hospital of Gansu Province, Lanzhou 730051, China | | Shihong Ma | Department of Head and Neck Surgery, The Cancer Hospital of Gansu Province, Lanzhou 730052, China | | Ruihui Chen | Department of Head and Neck Surgery, The Cancer Hospital of Gansu Province, Lanzhou 730053, China |
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| Abstract: |
| Objective: The purpose of the study was to investigate the effects of parathyroid hormone and parathyroid hormone receptor monoclonal antibody on in vitro growth and proliferation of human medullary thyroid carcinoma cell lines. Methods: The medullary thyroid carcinoma cell line was cultured in vitro, with parathyroid hormone and parathyroid hormone receptor monoclonal antibody treatment intervention, the growth of the cells was observed under an inverted contrast microscope, the MTT assay was used to detect the cell growth inhibition rate. Results: Under the inverted contrast microscope, the cells changed significantly, the parathyroid hormone and parathyroid hormone receptor monoclonal antibodies can effectively inhibit the proliferation of medullary thyroid cancer cells in a time and dose dependent. When parathyroid hormone concentration reached a concentration of 2.0 μmol/L, the parathyroid hormone receptor monoclonal antibody reached a concentration of 1.0 μmol/L, the cell growth was most significantly inhibited (P < 0.05). Conclusion: Parathyroid hormone and parathyroid hormone receptor monoclonal antibody were able to inhibit the proliferation of medullary thyroid carcinoma cells and significantly reduce the proliferation index. |
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