| Baoping Chang,Xiao Wang,Songsou Gao,Bianfeng Zhao,Wanli Wang,Shaohua Yang,Shiying Yu. Clinical signification of high-mobility group box 1protein (HMGB1) expression in infiltrating ductalcarcinoma breast tissue. Oncol Transl Med, 2014, 13: 215-219. |
| Clinical signification of high-mobility group box 1protein (HMGB1) expression in infiltrating ductalcarcinoma breast tissue |
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| KeyWord:infiltrating ductal carcinoma (IDC); high-mobility group box 1 protein (HMGB1); clinical staging; lymph node; estrogen receptor (ER); human epidermal growth factor receptor 2 (HER-2) |
| Author Name | Affiliation | | Baoping Chang | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan 430030, China | | Xiao Wang | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471001, China | | Songsou Gao | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471002, China | | Bianfeng Zhao | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471003, China | | Wanli Wang | Department of Oncology, The Second Affiliated Hospital of Henan University of Science and Technology,
Luoyang 471004, China | | Shaohua Yang | KingMed Diagnostics, Zhengzhou 450000, China | | Shiying Yu | Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and
Technology, Wuhan 430038, China |
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| Abstract: |
| Objective: Exploring the clinical signification of high-mobility group box 1 protein (HMGB1) expression in infiltrating ductal carcinoma (IDC) breast tissue. Methods: The expression of HMGB1 protein in IDC breast tissue was detected by immunohistochemistry, and the relations among size of tumour, lymph node metastasis, clinical staging, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2) were also analyzed. Results: Forty-six cases out of 60 cases of IDC breast tissue showed positive or strong positive HMGB1 expression (76.67%), statistical significance was observed between HMGB1 expression with clinical staging (P < 0.01), lymph node metastasis (P < 0.01), breast cancer ER (P < 0.05) and HER-2 (P < 0.05), however same conclusion can not be drawn between HMGB1 with either size of tumour or PR expression (P > 0.05) in IDC breast tissue. Spearman analysis showed negative correlation between HMGB1 expression and ER, and positive correlation between HMGB1 expression and clinical staging, lymph node metastasis together with HER-2. Conclusion: It’s promising that HMGB1 expression in IDC tissue can be one of biological indicators of poor prognosis. |
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