| Weiying Li,Wentao Yue,Niu Niu,Lina Zhang,Xiaoting Zhao,Li Ma,Xuehui Yang,Chunyan Zhang,Yue Wang,Meng Gu. Expression and significance of cyclooxygenase-2 in human lung cancer. Oncol Transl Med, 2014, 13: 203-206. |
| Expression and significance of cyclooxygenase-2 in human lung cancer |
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| KeyWord:cyclooxygenase-2; lung neoplasms; immunohistochemistry |
| Author Name | Affiliation | | Weiying Li | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101149, China | | Wentao Yue | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101150, China | | Niu Niu | General Department, Beijing Chest Hospital, Capital Medical University, Beijing 101149, China | | Lina Zhang | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101152, China | | Xiaoting Zhao | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101153, China | | Li Ma | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101154, China | | Xuehui Yang | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101155, China | | Chunyan Zhang | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101156, China | | Yue Wang | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101157, China | | Meng Gu | Cell Biology Laboratory, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital,
Capital Medical University, Beijing 101158, China |
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| Abstract: |
| Objective: We aimed to examine the expression of cyclooxygenase-2 and the relationship with the pathological types, TNM stage, lymph node metastasis, the degree of differentiation, smoking and the survival. Methods: Immunohistochemical staining method was used to examine the expression of cyclooxygenase-2 of 121 cases of lung cancer and three control groups. The data were statistically analyzed. Results: Compared with the health group, cyclooxygenase-2 was over expressed in the inflammatory tissue (P = 0.036), lung adenocarcinoma (P = 0.005) and squamous carcinoma (P = 0.047). Compared with patients without lymph node metastasis, cyclooxygenase-2 was over expressed (P = 0.033) in patients with lymph node metastasis. Compared with high differentiation group, cyclooxygenase-2 was over expressed (P = 0.004) in low differentiation group. Compared with non-smokers, the expression of cyclooxygenase-2 increased in smokers (P = 0.000). The median survival time of patients that the expression of cyclooxygenase-2 were negative was 9 months (95% CI, 5.6–12.4 months). The median survival time of patients that the expression of cyclooxygenase-2 were positive was 5 months (95% CI, 3–7 months). They was statistical difference (P = 0.001). Conclusion: Overexpression of cyclooxygenase-2 is associated with pathological types, TNM stage, lymph node metastasis, degrees of differentiation, smoking and prognosis in lung cancer. |
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