Xiaojun Deng,Jianwei Cao,Feng Liu,Weifeng Wang,Jidong Hao,Jiansheng Wan,Hui Liu. Optimizing prostate biopsy for repeat transrectal prostate biopsies patients. Oncol Transl Med, 2014, 13: 174-176.
Optimizing prostate biopsy for repeat transrectal prostate biopsies patients
  
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KeyWord:biopsy; prostate cancer; detection rate
Author NameAffiliation
Xiaojun Deng Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201318, China 
Jianwei Cao Department of Urology, Military 411 Hospital, Shanghai 200081, China 
Feng Liu Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201320, China 
Weifeng Wang Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201321, China 
Jidong Hao Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201322, China 
Jiansheng Wan Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201323, China 
Hui Liu Department of Urology, Pudong New Area Zhoupu Hospital, Shanghai 201324, China 
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Abstract:
      Objective: Diagnosis of patients with negative prostate biopsy and persistent suspicion of prostate cancer remains a serious problem. In this study, we investigated the application of optimizing prostate biopsy for patients who need repeat prostate biopsy. Methods: In this prospective, non-randomized phase-I clinical trial, the prostate cancer detection rate of initial detection scheme was compared with optimizing prostate biopsy scheme. The number of punctures of initial detection scheme was the same as that of optimizing prostate biopsy scheme. The puncture direction of optimizing prostate biopsy was a 45° angle to the sagittal plane from front, middle, and back. The two cores from each lateral lobe were horizontally inwardly inclined 45°. Results: A total of 45 patients with initial negative biopsy for cancer were received the optimizing prostate biopsy scheme. The cancer detection rate was 17.8% (8/45), and prostate intraepithelial neoplasm (PIN) was 6.7% (3/45). The patients receiving repeat transrectal prostate biopsies were pathologically diagnosed as lower Gleason grade prostate cancers. Conclusion: The cancer detection rate of repeat biopsy prostate cancer is lower than that of initial biopsy. Our study showed that the optimizing prostate biopsy is important to improve the detection rate of repeat transrectal prostate biopsies patients.
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