Chaoming Zhang,Weihua Li,Xiaodong Zhao,Yanpeng Zhu,Huiwen Shi. Expression and significance of ER and PR in differentiated thyroid carcinoma. Oncol Transl Med, 2014, 13: 149-152.
Expression and significance of ER and PR in differentiated thyroid carcinoma
  
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KeyWord:differentiated thyroid carcinoma (DTC); estrogen receptor (ER); progesterone receptor (PR)
Author NameAffiliation
Chaoming Zhang Qingdao University, Qingdao 266071, China 
Weihua Li Department of General Surgery, No. 401 Hospital of People’s Liberation Army, Qingdao 266071, China 
Xiaodong Zhao Department of General Surgery, No. 401 Hospital of People’s Liberation Army, Qingdao 266072, China 
Yanpeng Zhu Department of General Surgery, No. 401 Hospital of People’s Liberation Army, Qingdao 266073, China 
Huiwen Shi Department of General Surgery, No. 401 Hospital of People’s Liberation Army, Qingdao 266074, China 
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Abstract:
      Objective: The aim of the study was to investigate the relationship between expressions of estrogen receptor (ER), progesterone receptor (PR) and gender, age, tumor size, lymph node metastasis, capsular invasion and histological type of differentiated thyroid carcinoma (DTC). Methods: Seventy cases of DTC who received surgery in our hospital (No. 401 Hospital of People’s Liberation Army, Qingdao, China) between January 2008 and December 2011 were selected. Among them, 61 cases were papillary carcinoma and 9 cases were follicular carcinoma. Twenty cases were normal thyroid tissue adjacent to the tumor which was used as control. Immunohistochemical SP method was employed to detect the expression of ER and PR. Results: The positive rates of ER and PR in tumor tissues of DTC patients were 21.4% (15/70) and 31.4% (22/70), respectively, and no expression of ER or PR were founded in normal thyroid tissue (P < 0.01). The expressions of ER and PR were related to the lymph node metastasis and capsular invasion (χ2 = 16.913 and 6.327, P < 0.05; χ2 = 7.516 and 12.727, P < 0.05). No relationship was observed between the expressions of ER/PR and gender, age, and histological type (P > 0.05) of DTC patients. Conclusion: The expression levels of ER and PR in the tumor tissue of DTC patients were higher than those in the normal thyroid tissue nearby the tumor. Therefore, ER and PR expression might be clinical markers for DTC and its prognosis.
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